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Miroslaw,
AAG (alpha-1 acid glycoprotein) is raised above normal in
conditions associated with physiological stress, and is referred
to as an acute phase reactant. Elevated concentrations have been
associated with acute myocardial infarction, renal transplantation,
surgery, malignancy, ulcerative colitis, and Crohn's disease. Liver
disease is not associated with decreased levels, although there
is significant variation in cirrhotic patients with levels above/below
normal reported. Pregnancy and oral contraceptives lower levels of
AAG.
Within 8-12 hours after the onset of infection or trauma, the
liver increases the synthesis of the acute phase proteins, which
includes AAG, but of which c-reactive protein is the most notable as
an indicator of disease processes.
Dugs known to bind to AAG include dipyridamole, quinidine,
imipramine, propranolol, lidocaine, methadone, disopyramide and
other basic drugs.
I am not aware of any pharmacokinetic parameters for AAG, and
being an acute phase reactant, such parameters may not be readily
available. However, you may consult several reviews of plasma
protein binding.
However, Applied Clinical Pharmacokinetics 3rd edition does
tabulate some pharmacokinetic parmaeters for plasma proteins
including AAG:
T1/2 5.5 days
Conc 55-140mg/dl
Synt Liver
Cata Liver
Mike Leibold, PharmD, RPh
ML11439goodnet.com
References
1) Gibaldi, M., Prescott, L., Handbook of Clinical Pharmacokinetics,
ADIS press, New York 1983
2) Cecil Textbook of Medicine 19th edition
3) Evans, W.E. et al, Applied Clinical Pharmacoknetic 3rd ed., Applied
Therapeutic, Vancouver 1986
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)