Back to the Top
The following message was posted to: PharmPK
hi everybody,
i am studying on the in vitro in vivo correlation ship
and use of various models to establish the
relationship but i lack the data for the study. can
anybody suggest me the literature sources from which i
can have some data (eg. plasma conc vs time or amount
of drug release vs time etc) of bioavailabily study
and dissolution study of any drug or drug formulation.
thank you very much.
Sanjay Patel
Department pharmaceutical sciences,
Creighton University,
Omaha, NE 68131
Back to the Top
The following message was posted to: PharmPK Try:
Sandberg-Eur-J-Clin-Pharmacol-33-S3-1988
Regardh-J-Pharmacokin-Biopharm-2-4-347-1974
these give data for metoprolol. Saturable metabolism and protein
binding complicates it a bit but you can use a fixed first pass of
about 50% to start - but if you want to do it correctly, you should
use a nonlinear kinetics model with saturable metabolism and account
for protein binding. GastroPlus(tm) handles this very nicely.
Walt Woltosz
Chairman & CEO
Simulations Plus, Inc. (SIMU)
1220 W. Avenue J
Lancaster, CA 93534-2902
U.S.A.
http://www.simulations-plus.com
Phone: (661) 723-7723
FAX: (661) 723-5524
E-mail: walt.aaa.simulations-plus.com
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)