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The following message was posted to: PharmPK
I'm looking for some information on the relationship between log P and
volume of distribution. Can anyone recommend papers that have looked at
correlating these ?
Thanks in advance for any suggestions,
Tony Jones
email: abj.aaa.taytech.com
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The following message was posted to: PharmPK
Check the following reference:
Prediction of the volume of distribution from in vitro data and use
for estimating the absolute extent of absorption.
Ritschel WA, Hammer GV .
Int J Clin Pharmacol Ther Toxicol. 1980 Jul; 18 (7) :298-316.
gary
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Hello,
The literature is abundant with QSPR papers. The following is a good
example.
Hinderling PH, Schmidlin O, Seydel JK. Quantitative relationships
between structure and pharmacokinetics of beta-adrenoceptor blocking
agents in man. J Pharmacokinet Biopharm. 1984 Jun;12(3):263-87.
Regards,
Joga Gobburu
Pharmacometrics,
CDER, FDA.
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)