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The following message was posted to: PharmPK
Dear readers,
I need to simulate data for a substance with a strange behaviour:
After constant infusion of 15 minutes there is a decline of the
concentration and then the concentration increases. tmax of the substance
is at 30 hours and after those 30 hours the concentration slowly
decreases.
The half life is 133 days. Does anyone have experience with such a strange
behaviour and could suggest a model for this?
Thanks a lot
Peter Schlattmann
Dr. Peter Schlattmann, MSc
Freie Universitaet Berlin
Psychiatrische Klinik
Labor fuer Klinische Psychophysiologie
Eschenallee 3
14050 Berlin
Tel:: 030-84458606
Fax: 030-84458393
Email. Schlattmann.at.medizin.fu-berlin.de
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