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The following message was posted to: PharmPK
Are any of you aware of the mechanism of hepatic metabolism of phentolamine?
We have a complicated cardiac baby with hepatic and renal failure
and it is being used in lieu of nitroprusside (avoiding cyanide and
thiocyanate accumulation) as a continuous infusion (see abstract
below).
I cannot find any information on Medline, Micromedex, AHFS, Goodman
and Gilman, Peds or Adult Drug Info Handbook, Evan's Applied
pharmacokinetics or Facts and Comparison.
All I can find is that it is hepatically metabolized and ~10% is
excreted unchanged in the urine.
Does anyone have any information about the pharmacokinetics of
phentolamine? I know not much is out there as it's usually a
one-time dose.
Thanks for any help in advance,
Gretchen
Unique Identifier
83229934
Authors
Berner M. Rouge JC. Friedli B.
Title
The hemodynamic effect of phentolamine and dobutamine after
open-heart operations in children: influence of the underlying heart
defect.
Source
Annals of Thoracic Surgery. 35(6):643-50, 1983 Jun.
Local Messages
Some years of journal owned by HMC Library-see journal list
Abstract
The hemodynamic effects of phentolamine alone and in combination
with dobutamine were studied in the immediate postoperative period in
two groups of children. Group 1 (N = 6; mean age, 152 months) had
open-heart operation for acquired mitral valve disease. Group 2 (N =
6; mean age, 60 months) had intracardiac repair for tetralogy of
Fallot. Before drug administration, cardiac index did not differ
between groups, but patients with tetralogy of Fallot had a higher
heart rate and smaller stroke volume index; systemic vascular
resistance was high in both groups. With phentolamine (10
micrograms/kg/min), cardiac index and stroke volume index increased
similarly in both groups (+ 13% for cardiac index in Group 1, +9% in
Group 2), while systemic vascular resistance, pulmonary vascular
resistance, and pulmonary wedge pressure decreased. When dobutamine
(5 micrograms/kg/min) was added, there was a further increase in
cardiac index in both groups, but it was greater in Group 1 (+17% vs
+12%, p less than 0.01, compared with phentolamine alone; +33% vs
+22%, p less than 0.01, compared with control). Systemic vascular
resistance remained unchanged and heart rate increased in both
groups, so that the left ventricular stroke work index increased.
Although stroke volume index increased significantly with dobutamine
in Group 1 (+11%, p less than 0.01), it remained unchanged in Group 2
(+3%, not significant). Thus in Group 2, dobutamine increased cardiac
index only by increasing heart rate. This suggests that the
relatively small, noncompliant left ventricle in patients with
tetralogy of Fallot cannot further respond to inotropic drugs by
increasing stroke volume index.
Gretchen Brummel, PharmD
Clinical Pharmacy Specialist in Pediatrics
Milton S. Hershey Medical Center
MC H079
Hershey, PA 17033-0850
tel: 717-531-7719
fax: 717-531-0709
pager: 717-531-8521 #0290
email: gbrummel.-a-.psu.edu
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The following message was posted to: PharmPK
Gretchen,
I suggest you perform a search using google.com. I did and came up with a
number of hits for phentolamine pk. I hope this helps.
Lou Ptak, Ph.D.
ptakl.-at-.iconus.com
Searched the web for pharmacokinetics of Phentolamine. Results 11 - 20 of
about 284. Search took 0.11 seconds.
References : depression, antidepressants and mood-brighteners
.... Parmax); Pharmacokinetics; Phenelzine (Nardil); Phenelzine;
Phenelzine/depression;
Phenelzine/GABA; Phenelzine : structure; Phenethylamine : structure;
Phentolamine; ...
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.... U, Koppermann U & Luhman R (1990) Systemic pharmacokinetics of
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"of" is a very common word and was not included in your search. [details]
Searched the web for pharmacokinetics of Phentolamine. Results 21 - 30 of
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