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The following message was posted to: PharmPK
Dr. Spiresgate,
There was a study recently published in the Journal of
Pharm Sci which addresses many of the issues mentioned in
your email such as organ blood flows and how to scale them to
the specific model you are studying:
Bjorkman, S. et al, Prediction of disposition of
midazolam in surgial patients by a physiologically
based disposition pharmacokinetic model, Journ of
Pharm Sci 2001; 90(9):1226-1241
Mike Leibold, PharmD, RPh
ML11439.at.goodnet.com
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)