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The following message was posted to: PharmPK
Dear all,
Just a stupid question of grammar.
I am used to write "PK/PD relationships" in my reports when more than one
effect (i.e. effect on coagulation AND effect on headacke) is adressed.
Someone tell me that I must write "PK/PD relationship" without "s" in all
cases.
So, relationships or relationship ??
Could somebody help me ?
Thanks a lot
Philippe VARIOL
[A PK/PD question? :-) My guess; a complete model would lead to a
relationship but talking about each effect would result in
relationships - db]
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[Two replies - db]
From: Nick Holford
Date: Thu, 31 May 2001 06:42:51 +1200
To: david.at.boomer.org
Subject: Re: PharmPK PK/PD relationship or PK/PD relationships ?
The following message was posted to: PharmPK
Philippe VARIOL wrote:
> Dear all,
> Just a stupid question of grammar.
The only stupid questions are those you dont ask :-)
> I am used to write "PK/PD relationships" in my reports when more than one
> effect (i.e. effect on coagulation AND effect on headacke) is adressed.
> Someone tell me that I must write "PK/PD relationship" without "s" in all
> cases.
>
> So, relationships or relationship ??
My opinion as a person born and bred and having lived most of my life
in England and therefore a natural authority on the use of English:
"The PKPD relationships describing the effect of aspirin on
coagulation and headache" is preferable to "The PKPD relationship
describing the effect of aspirin on coagulation and headache" because
almost certainly the model and parameters for aspirin on coagulation
are very different for these 2 types of effect. Therefore the plural
is preferable. If you use the singular it implies that there is only
one (identical) relationship.
PS: I encourage modellers to use "PK/PD" -> "PK+PD" because its an
abbreviation for pharmacokinetic and pharmacodynamic relationships
not pharmacokinetic divided by pharmacodynamic relationships. Or more
simply just "PKPD".
--
Nick Holford, Divn Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
email:n.holford.aaa.auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556
http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.htm
---
From: gilberto de nucci
Date: Wed, 30 May 2001 17:06:29 -0300
To: david.-at-.boomer.org
Subject: Re: PharmPK PK/PD relationship or PK/PD relationships ?
The following message was posted to: PharmPK
Dear all
On the same line, pharmacokinetics/pharmacodynamics relationship(s)
or pharmacokinetic/pharmacodynamic relationship(s)?
Giblerto
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