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The following message was posted to: PharmPK
Dear all,
does anybody know the turn over rates of plasma proteins in rats, dogs,
monkeys and man?
Regards,
Bernhard
--
Bernhard J. Ladstetter, Ph.D.
Institute of Pharmacokinetics and Metabolism
Merck KGaA
Germany
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The following message was posted to: PharmPK
Bernard,
In human physiology, albumin is sythesized by the liver at an
average of 12 gm/day, with a maximum rate of 15-50gm/day. The
average half-life of albumin is 17-20 days.
Mike Leibold,PharmD,RPh
ML11439.at.goodnet.com
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The following message was posted to: PharmPK
Here are the half life estimates in days (range) for human plasma proteins
Prealbumin: 1.9
Albumin: 19 (17-23)
alpha1AGP: 5.2 (5-7)
alpha1LP: 4.2-4.8
Haptoglobin:3.5-4.0
S(f6-9)(beta) lipoprotein: 3.1-3.4
Transferrin: 8.5 (7-10)
IgG: 18 (15-26)
IgA: 5-6.5
IgM: 5.1 (3.8-6.5)
Fibrinogen: 4.0-5.5
The literature source for this info is Schultze H.E. and Heremans J.F. in
Molecular Biology of Human Proteins, Elsevier, Amsterdam, 1966.
Hope this is helpful
Anup Zutshi Ph.D.
Pharmacokinetics and Metabolism
Pharmaceutical Product Development
Battelle Memorial Institute
Tel.No: (614) 424-5997
Fax: (614) 424-3268
E-Mail: zutshi.aaa.battelle.org
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