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Can anyone recommend a few articles on the topic of Polymorphism?
Specifically towards Pharmaceutical R&D.
Thank you in advance.
--
George D. 'Merlin' McCallion, Chemist
Sanofi-Synthelabo
Great Valley Parkway, GV-25
Malvern, PA 19355
United States
Office: 610.889.6294
Fax: 610.889.6367
E: medchem.aaa.adelphia.net
The following message was posted to: PharmPKBack to the Top
Dear Merlin:
Several excellent review articles have been recently published discussing
the effect of genetic polymorphism on drug metabolism and disposition, and
the role of pharmacogenetics on drug R&D. The following are some useful
citations:
Pfost DR. Boyce-Jacino MT. Grant DM. A SNPshot: pharmacogenetics and the
future of drug therapy. Trends in Biotechnology. 18(8):334-8, 2000 Aug.
Nakajima T. Aoyama T. Polymorphism of drug-metabolizing enzymes in relation
to individual susceptibility to industrial chemicals. Industrial Health.
38(2):143-52, 2000 Apr.
Arledge T, Freeman A, Arbuckle J, Mosteller M, Manasco P. Applications of
pharmacogenetics to drug development: the Glaxo Wellcome experience. Drug
Metab Rev. 2000 Aug-Nov;32(3-4):387-94.
A thorough Medline search should give you additional information.
Khalid Alkharfy
University of Pittsburgh
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