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The following message was posted to: PharmPK
Hi All,
Could anybody direct me to commercially available software for convolution
of plasma concentration profiles using in-vitro dissolution and unit impulse
response data for the purposes of developing an IVIVC?
Regards,
Sreevatsa Natarajan
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The following message was posted to: PharmPK GastroPlus(tm) from
Simulations Plus provides a very sophisticated method for such work,
accounting for the many factors that affect the final plasma
concentration-time curve, such as pH-dependent solubility, transit
times, variable permeabilities in different regions of the
gastrointestinal tract (Ka is *not* a constant!), degradation in the
lumen, metabolism, protein binding in plasma, feedback effect of
pharmacokinetics on absorption (yes, it is affected by
pharmacokinetics - most noticeably for long half-life drugs), etc.
If you leave out any one of these, you can get the wrong plasma
concentration-time curve. Although you might get away with it in some
instances, simple constant Ka models are not the way oral doses
behave in general.
Walt Woltosz
Chairman & CEO
Simulations Plus, Inc. (SIMU)
1220 W. Avenue J
Lancaster, CA 93534-2902
U.S.A.
http://www.simulations-plus.com
Phone: (661) 723-7723
FAX: (661) 723-5524
E-mail: walt.at.simulations-plus.com
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The following message was posted to: PharmPK
You can try the software package CTDB (Clinical Trials Data Base) a
version of which is available from the www page given in my signature.
Good luck,
Maria Durisova
Dipl.Engineer Maria Durisova, D.Sc.,
Senior Research Worker and
Scientific Secretary
Institute of Experimental Pharmacology
Slovak Academy of Sciences
842 16 Bratislava
Dubravska cesta 9
Slovak Republic
Phone/Fax: 00421 7 5477 5928
http://nic.savba.sk/sav/inst/exfa/durisova.htm
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)