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Dear Colleagues,
Does anybody know some references about human PK of cytokines (e.g.
IFNs, ILs...), having assessed or modeled the receptor mediated
clearance ? I mean the part of the elimination processed through
receptors internalization, which is expected to be non-linear.
Thanks in advance,
Emmanuel Tamchs, MD
Lausanne
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The following message was posted to: PharmPK
Dear Dr. Tamches,
The group of Professor Y. Sugiyama at Tokyo University, Japan, has done
a series of study on receptor internalization, down-regulation, and also
sophisticated modeling. I am sure you can find some papers from that
group that suits your requirement.
I hope this helps.
Yan-Ling HE, Ph.D.
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The following message was posted to: PharmPK
Emmanuel,
I know of several papers addressing receptor-mediated clearance of
granulocyte-colony stimulating factor. References are:
Terashi et al. Antimicrob Agents Chemother 1999;43(1):21-24.
Takatani et al. Antimicrob Agents Chemother 1996;40(4):988-991.
Regards,
Kristine Radomski Crews, Pharm.D., BCPS
Assistant Member
St. Jude Children's Research Hospital
Pharmaceutical Dept. Room D-1052
332 N. Lauderdale
Memphis, TN 38105
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