PharmPK Discussion - Blood volumes in physiologic compartments

• On 9 Apr 2007 at 14:59:11, Paul Hutson (prhutson.-at-.pharmacy.wisc.edu) sent the message
  

  
  The following message was posted to: PharmPK
  
  Does anyone have a reference for information on:
  1) the relative amount of blood in each major organ at a given time,
  including (arteries+arterioles) and (veins+venules)?
  
  2) the residence time of blood in each of the said compartments?
  Human data would be best, but animals would also be a welcome
  alternative.
  Thanks in advance.
  Paul
  --
  Paul R. Hutson, Pharm.D.
  Associate Professor
  UW School of Pharmacy
  777 Highland Avenue
  Madison WI 53705-2222
  
  

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• On 9 Apr 2007 at 15:10:17, "Bernard Murray" (Bernard.Murray.-at-.gilead.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Paul,
  
  For volumes I usually refer to Legett & Williams (1991)
  "Suggested reference values for regional blood volumes in
  humans" Health Physics 60, 139-154
  
  For average dwell times in major organs I divide the volumes
  by the standard flows in Davies & Morris.  I recognise that
  there may be some inaccuracies in doing that (e.g. I've heard
  values of 60% for the fraction of hepatic blood that is in
  the sinusoids).
  
  Maybe some PBPK readers have better values?
  
  All the very best,
  
  Bernard
  
  Bernard Murray, Ph.D.
  Senior Research Scientist
  Drug Metabolism, Gilead Sciences, Foster City CA
  
  

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