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we are concerned about the pharmacokinetic evaluation of a substance
with an irregular dosing interval. Doses are given twice a week, so
every three or four days, respectively (i.e. dosing on days 1, 4, 8,
11, 15, 18, 22 etc.). Concentrations have been determined after the
first dose and under multiple dosing conditions. Now we want to
investigate potential time-dependent changes in the pharmacokinetic
parameters. So, normally the AUC determined from time zero to
infinity after the first dose should be comparable to the AUC from
time of dosing to the end of the dosing interval (tau) under steady
state conditions. But because of the irregular dosing intervals we
have two different taus under multiple dosing conditions.
So we thought if it was correct to calculate the AUC for the multiple
dosing conditions over two dosing intervals (so for 1 week) and then
divide the resulting AUC by 2, to get an AUC value that would be
comparable to the AUC generated after the first dose.
Any suggestions or references are welcome!
Thanks in advance,
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