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Hi all,
I am eager to know whether dose volume has any effect on the
preclinical pharmacokinetics. For example, if a oral PK study in rats
with CMC suspension was done at 10 mg/Kg, in two instances: first at
10 mL/Kg & second at 5 mL/Kg, do we observe any difference?.I will be
glad if members share their views.Providing literature references will
be a huge help.
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Dear Chakradhar
It will be having impact on PK (Absorption) however it depends on the
solublity of the test article in the Vehicle.
Jaladi Rajasekhar
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