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The following message was posted to: PharmPK
Dear all,
I am working on clinical trial field protocol and It has been
suggested measuring drug level in filter paper. I am not familiar to
this technique. Does anybody know a guideline were I can have further
information?
Thanks in advance,
Daher.
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Develop your own Bio-analytical assay and follow the ICH guidelines or
your countries guidelines.
s.o.o
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The following message was posted to: PharmPK
Dear Daher
First I would like to ask the question, where from the filter paper
came in between? However, I think you need to develop a method similar
to finding concn in target organs while doing a tissue distribution
study. You need to soak the filter paper in a proper solution
(probably a buffer solution of appropriate pH), homogenize it using
tissue homogenizer, sonicate for few minutes then extract with a
proper solvent (for ex. Liquid Liquid Extraction method) and anlyze
it. I think it helps?
Dr.Srinivas Rao
DMPK Division
Lupin Research Park, Pune.
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