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Can anyone clarify the following query
For Enoxaparin Sodium,
whether the Anti Xa activity, PT, APTT & Heptest are coming under PK
or PD parameters (using kinetica software)
Immediate reply will be appreciated
Thanks
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The following message was posted to: PharmPK
Sujatha
> For Enoxaparin Sodium,
>
> whether the Anti Xa activity, PT, APTT & Heptest are coming
> under PK or PD parameters (using kinetica software)
Anti-Xa is a reasonable surrogate for enoxaparin concentrations - and
hence
more closely represents PK. PT and aPTT are definitely PD observations.
Linking between these is (as I'm sure you're aware) non-trivial.
Steve
--
Professor Stephen Duffull
Chair of Clinical Pharmacy
School of Pharmacy
University of Otago
PO Box 913 Dunedin
New Zealand
E: stephen.duffull.at.otago.ac.nz
Design software: www.winpopt.com
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