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The following message was posted to: PharmPK
I'll start a new thread here instead of adding to the thread on
waiting three doses before checking levels.
In the context of TDM history, I thought I would share a treasured
artifact from my PharmD program at the University of Tennessee at
Memphis in 1980. Prof Art Straughn developed a 'PK slip-stick' that
could be used in PK calculations, very handy when the calculator was
not in your pocket. I keep it with my Pickett slide rule in my drawer,
for those students who declare during an exam that the batteries in
their calculator have failed. The expression on their face is
priceless ;-)
I've loaded an image for viewing by interested parties at:
https://mywebspace.wisc.edu/prhutson/web/Straughn%20Kinetic%20Slide%20Rule.jpg
--
Paul R. Hutson, Pharm.D.
Associate Professor
UW School of Pharmacy
777 Highland Avenue
Madison WI 53705-2222
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Paul,
Thanks for your fond memory of what most students back then regretted.
You might not believe this; but in recent years, I have been contacted
by people who have, or had, one that actually want to purchase another.
The "rulers" were distributed by Harvy A.K Whitney until the mid 80's,
but I understand from him they are no longer available. For those
interested I do have some paper prototypes (somewhat different slide
mechanics) that require assembly. I will be glad to share them with
anyone interested. No instruction manual, but a description on its use
can be found at: "Estimations of Drug Dosing Regimens with a
Pharmacokinetics Slide Rule", Straughn AB, Cruze CA and Meyer MC, Am. J.
Hosp. Pharm., 34:197 (1977).
Art Straughn, Pharm.D.
Professor Emeritus and Director
Drug Research Laboratory
Department of Pharmaceutical Sciences
5P Crowe, 874 Union Ave
Memphis, TN 38163
astraughn.at.utmem.edu
[I wonder if pdfs of the paper version could be prepared for download?
- db]
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Paul:
It is good gesture to remind people the pre-PC-NONlin days tools of PK
slide ruler, folks who are interested in the advent of PK and TDM in
clinical practice should read early papers of Professor Gerhard Levy,
(something like Significant numbers or Significant nonsense? etc) this
gives an insight into the troubles of young looking Art Straughn (he
is not that old to be a History) and others went through.
Prasad
Prasad NV Tata, MS, Ph.D., FCP
Manager-Pharmacokinetics
Mallinckrodt, Inc.
675 McDonnell Blvd.
Saint Louis, MO 63134
e-mail: prasad.tata.-at-.covidien.com
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The following message was posted to: PharmPK
With Art's kind permission I have placed a pdf of a prototype of his
PK slide rule at:
http://www.boomer.org/pkin/images/AS_PK_sliderule.pdf
Art has also offered to provide the individual pieces already cut for
pasting. Please contact him directly at astraugh.-at-.utmem.edu if
interested.
The reference for the slide rule is: AB Straughn, CA Cruze, and MC
Meyer Estimation of drug dosage regimens with a pharmacokinetic slide
rule, Am J Health Syst Pharm 1977 34: 197-200
Abstract:
http://www.ajhp.org/cgi/content/abstract/34/2/197
David Bourne
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