Back to the Top
Hi,
Can anybody tell me relationship between plasma protein binding-
IC-50, Efficacy and distribution.
The compound I've worked has show IC-50 value in uM concentration, it
has 98% protein binding. When give in rat and mice shows enough
concentration in liver (target organ, concentration are much above
IC-50 values), but when given in Chimeric mice activity is not found.
Unfortunately we don't have the data of liver expose level. Can
someone predict possible reason for the same.
If somebody can give me reference or reviews on this topic will be
highly appreciated.
Thanks and regards,
Vijay
Back to the Top
The following message was posted to: PharmPK
If this is for hcv what is the potency in the replicon assay?
Protein binding is less important in HCV than HIV.
Dominique
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Plasma protein binding-IC-50, Efficacy and distribution" as the subject | Support PharmPK by using the |
Copyright 1995-2011 David W. A. Bourne (david@boomer.org)