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Hi Dev,
I think there are many publications in journal of DMD (drug metabolism
and disposition)
http://dmd.aspetjournals.org/
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Dear Dev,
The following three papers contains tissue distribution data and
references to the original articles.
Jansson R, Bredberg U, Ashton M.
Prediction of drug tissue to plasma concentration ratios using a
measured volume of distribution in combination with lipophilicity. J
Pharm Sci. 2008 Jun;97(6):2324-39.
Rodgers T, Rowland M.
Physiologically based pharmacokinetic modelling 2: predicting the
tissue distribution of acids, very weak bases, neutrals and
zwitterions. J Pharm Sci. 2006 Jun;95(6):1238-57.
Rodgers T, Leahy D, Rowland M.
Physiologically based pharmacokinetic modeling 1: predicting the
tissue distribution of moderate-to-strong bases. J Pharm Sci. 2005 Jun;
94(6):1259-76.
Kind regards,
Rasmus Jansson
--
Rasmus Jansson Loefmark
Unit for Pharmacokinetics and Drug Metabolism
Goeteborg University
P.O.Box 431, SE-405 30 Goeteborg
Sweden
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