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Hi,
I'd like to know what the "correct" abbreviation for the maximum (or minimum) concentrations at steady state or time to reach this concentration are. I have seen both Css,max and Cmax,ss with corresponding tss,max and tmax,ss for the time to reach the maximum concentration.
Best regards,
Toufigh
Toufigh Gordi, PhD
Clinical Pharmacology, PK/PD analysis consultant
www.tgordi.com
E-mail: tg.-at-.tgordi.com
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The following message was posted to: PharmPK
I'm not sure which is correct, but if I had to report that parameter, I would check with Rowland and Tozer and use Css,max where "ss,max" is a subscript. See page 99 of Rowland and Tozer, Clinical Pharmacokinetics 3rd edition.
Tae
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Hi Tae,
Thanks for the reply. That would also be my preference. However, the time to reach Css,max would then be tss,max, which somehow doesn't sound correct in my ears.
Toufigh
Toufigh Gordi, PhD
Clinical Pharmacology, PK/PD analysis consultant
www.tgordi.com
E-mail: tg.-a-.tgordi.com
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Dear Dr.Toufigh Gordi,
I would prefer to use Css max and tss max as most of the standard books use the above abbreviations.
References:
1. Larry A. Bauer, Applied Clinical Pharmacokinetics, 2nd Edition, McGraw Hill Professional, 2008.
2. Praveen Tayle, Drug delivery devices: Fundamentals and applications, Informa Healthcare, 1998.
3. Paul G.Perason, Larry C.Wienkers, Handbook of Drug metabolism, Informa Healthcare, 2009.
4. James Swarbrick, James C.Boylan, Encyclopedia of pharmaceutical technology, Volume 2, Marcel Dekker, 2002.
5. Milo Gibaldi, Mary Lee, Archana Desai, Drug Delivery systems in Pharmaceutical care, ASHP, 2007.
6. Thomas F.Woolf, Handbook of drug metabolism.
Thanks & Regards,
Dr.S.Gunasakaran, MD
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It seems that there is no uniform or standardized symbols in PK books. Every author will use their own one. Will things get standardized one day?
Best regards,
Imran
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I've mentioned the following useful reference before (sorry if you have seen it):
Rowland M and Tucker G (1980) Symbols in pharmacokinetics. J Pharmacokinet Biopharm 8:497-507
http://www.ncbi.nlm.nih.gov/pubmed/7252793?dopt=Citation
Regards
Masoud
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The following message was posted to: PharmPK
The Association for Applied Human Pharmacology (AGAH) Working Group on PK-PD modeling put together a glossary:
"Collection of terms, symbols, equations, and explanations of common pharmacokinetic and pharmacodynamic parameters and some statistical functions".
It can be found at the address:
http://www.agah.info/uploads/media/PK-glossary_PK_working_group_2004.pdf
I think it is very useful and can be a starting point for the harmonization of the symbols.
radu
Pharma Medica Research Inc.
Canada
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