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The following message was posted to: PharmPK
Dear all,
i have a question regarding the determination of the free drug
concentration or the Fu in the blood.
I feel that the concentration that we get in the blood while
performing the blood-plasma partioning assay should be utilised for
calculation of the free drug concentration..
please correct me if i am wrong, and suggest me how to do the free
fraction assay in blood
..k.v.bhargava
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You can calculate the amount free in blood. Amount free in blood is equal to the free fraction in plasma divided by the blood to plasma ratio.
Stanley Cotler
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