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Does anyone have experience with oral administration of macrogol 15 hydroxystearate (solutol, manufacturer is BASF) to humans? What is the maximum dose, which can be administered?
Kind regards
Corinne
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The following message was posted to: PharmPK
Dear Corinne,
Please look at Smith et al 1988 Br. J. Cancer, 57, 623-627. Although solutol has been used in approved products in Canada, Sweden, Argentina and India (and is almost impossible to get any detailed info regarding dose) I would try to find an alternative as much as possible. Unless you are working in a terminal disease indication and under a controlled clinical setting where patients are monitored closely I would not use solutol.
Rostam
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