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Hi,
I have a potentially naive question. Is there literature documenting that %CV's in monkeys is typically lower than in healthy human volunteers in cross-over PK studies?
Perry
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%CV for what? If your are discussing a physiological or biochemical parameter it is quite likely that the scatter about the mean might be lower since a species of monkey represents a more homogenous group than do humans. If you are addressing bioanalytical results, the same might also be true since the bioanalysis is the composite of an analytical variance and species variance.
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Thank you Ed,
You replied to the question just as I had hoped someone would to make a
point to one of my Senior Directors. They sometimes need to hear an answer
from an outside source to believe it.
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