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Dear All
Can any give reference or view how we can consider drug is highly, moderate, or low permeable from in-situ studies. Is there any limit for the same. It will be great if any one can give reference for the same.
Thanking you in advanced.
NIL
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The following message was posted to: PharmPK
Many years ago I published a paper in J Pharm SciVol61, No 9, Sept 1972 pp1361-1365. It states in the everted Intestinal Sac can only predict the potential for absorption. We have some examples in the paper that did correlate well with in-vivo comparisons.
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