Back to the Top
Dear colleagues,
I have question about the normalization of AUC and Cmax.
Patients who involved into clinical trial usually have big variation of body weight and the dosage. I read some references. The author usually normalized AUC and Cmax by using dosage and body weight or both of them, such as (AUC/Dosage) or (AUC/Dosage/Weight)
I can understand the normalization of AUC by using dosage. But why AUC can be normalized by using body weight? Does the Cmax really need to be normalized?
Best regards,
Xiaoming
|
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "How to normalize the AUC and Cmax" as the subject | Support PharmPK by using the |
Copyright 1995-2011 David W. A. Bourne (david@boomer.org)