Back to the Top
I have been looking for blood flow values in mouse organs but I don't
find the information (except for liver that was reported here). I am
interested in the following organs:
liver, spleen, lungs, kidneys, brain and heart.
Also, in other tissues like fat and membrane-like tissues like
stomach and intestine.
Any suggestion on the values or references where I could find them
would be greatly appreciated.
Thanks
Ignacio
Ignacio Segarra, Ph.D.
BioDelivery Sciences, Inc.
Department of Biopharmacy and Pharmacokinetics
University Heights Science Park
111 Lock Street
Newark, NJ 07103
Phone: (973) 972-0322
Fax: (973) 972-0323
Back to the Top
[A few replies - db]
Date: Wed, 10 May 2000 09:07:02 +0200
From: "Haddad, Sami {PRNS~Basel}"
Subject: PharmPK RE:
To: "'PharmPK.-at-.boomer.org'"
Dr Segarra,
You will be able to find the blood flow for several organs of mice in
the following article:
Brown et al. (1997) Toxicology and Industrial Health 13: 407-484.
I hope this will help you.
Sami
Sami Haddad
Hoffmann-La Roche Ltd
PRNS 69/139
4070 Basel
e-mail sami.haddad.aaa.roche.com
FAX 0041-61-6882908
phone 0041-61-6885608
---
Date: Wed, 10 May 2000 01:27:35 -0700 (MST)
X-Sender: ml11439.-at-.pop.goodnet.com
To: PharmPK.-a-.boomer.org
From: ml11439.aaa.goodnet.com (Michael J. Leibold)
Subject: Re: PharmPK Blood flow in mouse organs
Ignacio,
Here are some references in which organ blood flow rates in mice are
reported:
1) King, F.G., Dedrick, R.L., Pharmacokinetic model for 2-amino-1,3,4-
thiadazole in mouse, dog and monkey, Cancer Treat Rep 1979;63:1939
2) Bischoff, K.B., Dedrick, R.L., Zaharko, D.S., Longstreth, J.A.,
Methotrexate pharmacokinetics, J.Pharm Sci 1971;60:1128
3) Bischoff, K.B., Dedrick, R.L., Zaharko, D.S., Preliminary model for
methotrexate pharmacokinetics, J.Pharm Sci 1970;59:149
Mike Leibold, PharmD, RPh
ML11439.-at-.goodnet.com
---
From: "Melethil, Srikumaran K."
To: "'PharmPK.-at-.boomer.org'"
Subject: RE: PharmPK Blood flow in mouse organs
Date: Wed, 10 May 2000 10:21:15 -0500
Dear Ignacio,
Papers on physiologically-based PK models should contain such information. Two
papers by Dedrick et al 1970-1973 has organ blood flow information in mice and
(rats too, I think. Hope this helps.
Sri
Srikumaran Melethil, Ph.D.
Professor of Pharmaceutics and Medicine
University of Missouri-KC
203 B Katz Hall, School of Pharmacy
5005 Rockhill Road
Kansas City, MO 64110
816-235-1794 (voice); 816-235-5190 (fax)
---
Back to the Top
>...segarrig.-at-.UMDNJ.EDU asked about blood flows...>
The best place to start is this article (then I guess, you will need to scale
it allometrically - depending on body weight and total cardiac output):
Brown RP, Delp MD, Lindstedt SL, Rhomberg LR, Beliles RP:
Physiological parameter values for physiologically based pharmacokinetic
models.
Toxicol Ind Health 1997 Jul-Aug;13(4):407-84
Best wishes.
Janusz Z. Byczkowski, Ph.D.,D.Sc.,D.A.B.T.
Consultant
212 N. Central Ave.
Fairborn, OH 45324
phone (937)878-5531
Office (614)644-3070
confidential fax (603)590-1960
e-mail januszb.at.AOL.com
homepage: http://members.aol.com/JanuszB/index.html
JZB Consulting web site: http://members.delphi.com/januszb/
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)