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Dear all
I'm looking for azithromycin's pharmacokinetics (absorption and
elimination constants, main distribuition characteristics, etc). Can
anyone help me on this? A bibliographic reference would be precious.
Thanks in advance
Best regards
Nuno
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Please look at the following articles they may be help full for your purpose
Najib NM, Idkaidek, N Ghanem IE..., Bipharm Drug Dispos. 2001, Jan
22(1):15-21
Gulati R, Tripathi CD, Chandra D., J. Assoc Physiation India 2000, Jun
48(6):606-8
Sibel
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I have provided you with the references below, plus some data that is
currently under the review process for ball pythons and blue & Gold
macaws with two different journals, should you be interested.
R.P. Hunter, M.J. Lynch, J.F. Ericson, W.J. Millas, A.M. Fletcher, N.I.
Ryan, & J.A. Olson (1995) Pharmacokinetics, oral bioavailability and
tissue distribution of azithromycin in cats. Journal of Veterinary
Pharmacology and Therapeutics, 18, 38-46.
Shepard, RM, Falkner FC. Pharmacokinetics of azithromycin in rats and
dogs. J Antimicrob Chemother 1990;25(suppl A):49-60.
Foulds G, Shepard RM, Johnson RB. The pharmacokinetics of azithromycin
in human serum and tissues. J Antimicrob Chemother 1990;25(suppl
A):73-82
Davis, J.L., Gardner, S.Y., Jones, S.L., Schwabenton, B.A., & Papich,
M.G. (2002) Pharmacokinetics of azithromycin in foals after i.v. and
oral dose and disposition into phagocytes. Journal of Veterinary
Pharmacology & Therapeutics, 25, 99-104.
Girard, A.E., Girard, D., English, A.R., Gootz, T.D., Cimochowski,
C.R., Faiella, J.A., Haskell, S.L., & Retsema, J.A. (1987)
Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new
macrolide with an extended half-life and excellent tissue distribution.
Antimicrobial Agents and Chemotherapy, 31, 1948-1954.
Peters, D.H., Friedel, H.A., & McTavish, D. (1992) Azithromycin. A
review of its antimicrobial activity, pharmacokinetic properties, and
clinical efficacy. Drugs, 44, 750-799.
Rob Hunter, MS, PhD
Assistant Professor of Veterinary Pharmacology
Zoological & Analytical Pharmacology Laboratory
Department of Anatomy & Physiology
129 Coles Hall
College of Veterinary Medicine
Kansas State University
Manhattan, Kansas 66506-5802
rhunter.aaa.vet.ksu.edu
www.vet.ksu.edu/depts/ap/faculty/hunter.htm
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)