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Dear all,
I am looking for a literature reference on the comparative bioavailability
of amlodipine besylate in fed versus fasting state in humans.
Thanks for help
Marko Boh, MD
Slovenia
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This may help you answer your question
Arzneimittelforschung 1989 Jul;39(7):799-801
Absorption of amlodipine unaffected by food. Solid dose equivalent to
solution dose.
Faulkner JK, Hayden ML, Chasseaud LF, Taylor T.
Department of Clinical Research, Pfizer Central Research, Sandwich, UK.
The oral bioavailability of amlodipine in healthy volunteers was compared in
two separate studies after solution and capsule doses, and after capsule
doses in fed and fasting states. The bioavailability of amlodipine was
equivalent both in terms of rate and in extent of absorption between
solution and capsule doses and in the fed and fasting states.
PMID: 2528959 [PubMed - indexed for MEDLINE]
Robert S. York
MS II
LSU Medical School in Shreveport
(318) 798-5696
ryork.-at-.lsuhsc.edu
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