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The following message was posted to: PharmPK
Some ideas on perfusion with regard to the contribution of Robert D.
Phair, Ph.D. rphair.at.ix.netcom.com
Dear colleague,
I found this comment from you in the web while searching for viewpoints
on perfusion.
I've developed a software to quantify perfusion from digital
color-duplexsonographic videos and apply this in many clinical
situation.
While presenting my results some questions always arose: what is
perfusion? You refer to the common definition that is well accepted -
o.k.
But is another perception possible? I would like to ask you if one could
not describe a perfusion as a volume of blood passing a plane in a
certaim time to flow into parts os the vasculature and surrounding
tissues behind that (imaging )plane?
This is my point of view - it makes something much easier: You can
maesure the volume of blood streaming throh a plane - may be the imaging
plane odf a vessel and you can say - the whole tissue behind that plane
is perfused with this amount of blood - without arguing how lartge the
organ might be. in many cases - e.g. bowel loops - you cannot qauntify
the blood flow in this conventional wyay - my proposal is to quantify
perfusion in amn organ by measuring the blood flow through a plane of
imaging. What do you think abaout this? I have excellent results with
this algorithm in many clinical situations A clinician wnats to know how
strong the perfusion is and often doesn't need to know which volem of
bloosd is runnong through wich VOLUME of tissue in which time. This
older and still prevailing pint of view may be helpful in physiologic
labs when you can simply cut out an organ determine it's volume and the
volume of blood flowing throug . In clinical situations this is a blind
way. Please tell me what you think about this - as a physiologist. If
you like see my software at www.chameleon-software.de (PixelFlux). Thank
you.
Regards - Thomas
mit freundlichen Gr§en
Priv.-Doz. Dr. Thomas Scholbach
Kinderklinik am Stdtischen Klinikum "St. Georg" Delitzscher Str. 141
D - 04129 Leipzig
thomas.scholbach.-at-.sanktgeorg.de
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