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Does anyone know how daunorubicn is metabolized (CYP isoforms)?
Alternatively, which drugs are known to interact with daunorubicin or
daunorubicinol (active metabolite)?
Similar info on doxorubicin would also be very useful.
Thanks,
Varun
Vertex Pharmaceuticals, Inc.
130 Waverly Street
Cambridge, MA 02139
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A clinician's guide to chemotherapy pharmacokinetics and
pharmacodynamics by Louise Grochow and Matthew Ames has good reviews of
metabolism of doxorubicin, with some reference to daunorubicin.
Most of the text concentrates on the carbonyl reductase step to
doxorubicinol, and the NADPH-dependent reduction to 7-deoxyaglycone
metabolites. Surprisingly the author claims that cytochrome p450s are
not involved in anthracycline metabolism, yet Medline searches do not
yield much to say otherwise.
I would be interested to know if anyone knows specific references about
anthracyclines and CYP450, or even just opinion on what reasons we have
to believe they are involved.
S. Brown
Clinical Research Fellow
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Daunorubicin is metabolised by aldo-keto reductase. The following
reference may be useful, Comparative mammalian metabolism of adriamycin and
daunorubicin. Lovless,H.; Arena,E.; Felsted,R.L.; Bachur,N.R. Cancer Res.38
593-598 (1978). If you do a medline search on Bachur, you will probably find
most of the paper on daunorubicin metabolisim, most of this work was done in
the 70's.
As far as I'm aware P450's are not involved in daunorubicin metabolism.
Peter
Peter Galettis
Cancer Care Centre
St George Hospital
Gray St, Kogarah
NSW 2217
galettisp.at.sesahs.nsw.gov.au
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)