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The following message was posted to: PharmPK
Dear All,
The drug which is Hydrophobic in nature is insoluble
in water , slightly soluble in Methanol, Acetonitrile.
For standard plot in Disssolution I could not dissolve
the substances in Acidic Buffer pH 1.2since the
formulation is uncoated tablets.I have tried
surfactants and 5 ml of organic solvents also. I could
not dissolve the substance . Please suggest me to
improve by dissolution of standard drug.
Thanking You,
Yours Sincerely,
Subramanian
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The following message was posted to: PharmPK
Have you consider the use of a continous flow dissolution device, like
apparatus 4, USP?. I may reproduce to some extent the hydrodinamic
regime of the gi tract, thus allowing for drainage of poorly soluble
drugs
Carlos Montuenga
Madrid Spain
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