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Dear Members,
What is the best possible way to calculate the "Extent
of Absorption".
Can I use the equation AUC(oral)/AUC(IV), where in
both AUC's are obtained by measuring the total
radioactivity, for estimating the extent of
absorption.
Thanks in advance.
Regards,
Sreeraj Macha
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Dear Sreeraj,
the use of AUC(oral)/AUC(iv), corrected with both iv and po doses is
used to
calculate the relative bioavailability of your drug.
To measure the extent of absorption I suggest that you calculate the
ratio
between the total radioactivity in the body after po dosing and the
radioactivity initially contained in your dosage form. That means: dose
absorbed/dose administered.
Hope this helps,
Frederic
PFIZER Global R&D
Fresnes Laboratories
FRANCE
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