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Janusz
When I am doing a population PK/PD exercise, I fixed the model,
simulate data, add intraindividual variability and get what I called
my "observed data". I shift then to the fitting mode where I am
fitting that model to the data using the fixed model (sorry for the
confusion between data to the model and model to the data) . My
point was that for a fixed model that is complex , the exercise I
suggest would show to what extent the parameter estimates are
reliable or not.
Serge Guzy
Head of Pharmacometrics
Xoma
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)