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[I've been changing mail servers (and web servers) for PharmPK and
managed to mess up a setting or two. Thus, you probably received
multiple (hopefully at most two) copies of some messages today...or
repeats of older messages. I think I've got the 'system' working
properly for now although I still need to add a few things etc.etc. -
BTW If you are interested I'm using Apache and sendmail under Mac OS
X - db]
Can somebody throw light on how to calculate Mean Dissolution Time (MDT)
from the In-vitro dissolution data. Any reference is appreciated.
Prasad Tata, Ph.D.
Mallinckrodt, Inc.
[This could be interesting - quick guess ;-) AUMC/AUC for the rate of
dissolution versus time data - db]
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[Two replies - db]
From: Paul CollierDate: Thu, 17 Jan 2002 09:12:04
+0100
To: david.at.boomer.org
Subject: Re: PharmPK
The following message was posted to: PharmPK
Dear Prasad,
A simple method for estimating Mean Dissolution Time (MDT) in vitro is
to plot the data as "amount remaining to be dissolved" versus "time" and
then calculate the area under the curve (AUC).
MDT = AUC/Dose
For further information see:
Collier, P.S. (1984). The interpretation of in vivo mean dissolution
time data. In: Pharmacokinetics : A Modern View. Eds. L.Z. Benet and G.
Levy. New York, Plenum Press, pp. 403-406.
Dr Paul S. Collier
School of Pharmacy
Queen's University, Belfast
97 Lisburn Road
Belfast BT9 7BL
N. Ireland, UK
---
From: "Durisova Maria"Date: Thu, 17 Jan 2002
11:34:36 +0100
To: david.-a-.boomer.org
Subject: Re: PharmPK Re: Mean Dissolution Time
The following message was posted to: PharmPK
Dear Prasad Tata,
I read your message concerning the MDT and MRT with great pleasure. Your
own reply is absolutely correct!
Using the system-approach modeling technology, model-based estimates of
mean times of
various bio-medical processes can be determined in a methodically,
conceptually, and computationally
uniform way.
In our recent papers we described utilization of this technology: 1. in
determination of a model-based estimate of the mean absorbtion time
(Dedik L, Durisova M.: Modeling drug absorption from enteric-coated
granules,
Meth Find Exp Clin Pharmacol 2001, 23: 213-217.) 2. in detremination of
a model-based estimate of the mean dissolution time
(Dedik L, Durisova M.: System-approach methods for modeling and testing
similarity of
in vitro dissolutions of drug dosage cormulations, Comput Methods
Programs Biomed 2001, accepted).
With best regards,
Maria Durisova
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