Back to the Top
Dear all
I am going to do experiments on rat to determine the pharmacokinetic
parameters of some herbal compounds.I would like to know your opinion
regarding the best rout of administration for this kind of
experiments.
Thank you for your cooperation
parvin zakeri
Back to the Top
Hello Parvin
Intravenous administration would be a good starting point.
Venkatesh Atul Bhattaram
Post-doctoral Fellow
University of Florida
Back to the Top
[Four replies - db]
From: "atul"
Date: Thu, 25 Apr 2002 22:21:03 -0700
To: david.aaa.boomer.org
Subject: Re: PharmPK Pharmacokinetic parameters of some herbal compounds
Status: RO
Hello Parvin
Intravenous administration would be a good starting point.
Venkatesh Atul Bhattaram
Post-doctoral Fellow
University of Florida
---
From: "O'Connor, Ed"
Date: Fri, 26 Apr 2002 07:48:19 -0400
To: david.-at-.boomer.org
Subject: RE: PharmPK Pharmacokinetic parameters of some herbal compounds
Probably want to do both oral and IV. In either case you might want to do a
pilot study using conscious restrained rat cannulated for sampling of venous
and arterial blood and for urine. THis prep Gellai and Valtin, AJP, KI
allows for BP, pulse and renal function as well as for sampling up to 4
hours. Once you get an Idea from that you could more finely tune your tox
and PK studies.
---
From: Candice Kissinger
Date: Fri, 26 Apr 2002 07:59:50 -0500
To: david.aaa.boomer.org
Subject: Re: PharmPK Pharmacokinetic parameters of some herbal compounds
We've been doing work on herbals for the past 2 years and are using rats
(Zucker Diabetic Fatty and Sprague-Dawley) as the animal model. We've used
both oral (gavage or metered additions to drinking water for stable
compounds) and IV administration.
Candice Kissinger
In Vivo Sampling Laboratory
Bioanalytical Systems Inc.
---
From: "Khan Ghilzai, Naushad"
Date: Fri, 26 Apr 2002 09:29:56 -0500
To: david.-a-.boomer.org
Subject: RE: PharmPK Pharmacokinetic parameters of some herbal compounds
Hello:
Is these herbal products are one of the indigenous systems of medicines
e.g., Ayurveda, Unani and Siddha?
Do you mind be more explicit on these products?
You can choose any route depending on what parameters you looking at?
I would assume that your ROA should be based on composition of your herbal
product.
Hope this helps
Thanks!!
Naushad Khan Ghilzai
Back to the Top
Dear Parvin:
It is better to do both oral and intravenous pharmacokinetics of
herbal product to get the correct profile of pharmacokinetics. To
start with intravenous route is advisable, most of the times, herbal
contents are either poorly absorbed or metabolzed extensively before
going into blood circulation.
Madhu
Back to the Top
My questions to all those folks advocating IV dosing for herbal products
are.
How advisable to have an IV herbal formulation?
Are there any commercially available IV herbal products?
IMHO in view of the safety concerns associated with herbal products, it is
better to do some relative BA studies rather than looking for ambitious
absolute BA.
My two cents... I could be wrong.
Prasad Tata
Back to the Top
In reference to the question by Prasad -- I guess it depends a lot on how
you are making the dose. If we're making infusions from leaves or flowers
(green tea, herbs, etc.) that doesn't seem worse (more toxic) than some of
the slurries that we are sometimes required to dose with when we have
compounds that are insoluble in physiological saline until they get a big
boost of DMSO, ethanol, soybean oil, Tween-80, or other excipients.
A lot of time, it seems we are already focused on a component present in
the herbal compound, and are just dosing with that (e.g. ECGC, resveratrol,
hypericin, etc.), which is no different than a standard NCE protocol.
Candice Kissinger
Bioanalytical Systems Inc.
Back to the Top
Hi, Prasad,
IV herbal formulations may not be common in the
US but there are many examples in China. They have
one or more traditional medicinal herbs formulated
into 1 or 2 mL injections. Details can be found in the
Chinese Pharmacopoeia.
Lawrence Lee
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)