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Hello,
I have been attempting to model some plasma concentration data
obtained following multiple IV infusions (q 6hrs, 113 doses) in
monkeys. I have noticed an interesting phenomenon in the data and
was wondering if others had seen this. With repeated dosing, the
peak-to-trough difference in plasma concentrations is increasing
significantly. The data fits best to a one-compartment model, and
the elimination half-life is not changing with time. Could this be
indicative of a decrease in the volume of distribution with time? If
so, what physiologic mechanisms might be responsible? Any ideas
would be greatly appreciated.
Thanks,
Jay
Jay Tibbitts D.V.M., Ph.D.
XOMA (US) LLC
2910 Seventh Street
Berkeley, CA 94710
[Is the difference increasing with the same C(average)? If yes, the
t(1/2) would have to change. Is the C(average) increasing, decreasing
or the same? - db]
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