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The following message was posted to: PharmPK
hi all
there is a molecule for topical application for which
preclinical pharmacokinetic data is to be generated.
we need to look in for systemic exposure after topical
application and also calculate its bioavailability.
however we are not been able to prepare a suitable
formulation for its intravenous dosing. so is it
possible to report its relative bioavailability after
oral administration and comparing the dermal
application data with the same. any refrences in this
regard will be of great help.
regards
nitin
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The following message was posted to: PharmPK
dear Nitin,
Its possible to use the oral solution as the standard for the
calculation of relative bioavialbility (oral absorption), there are
many cases wherein the absolute bioavailability is not established
because of formulation difficulties in preparing injectable form or
other reasons.(Eg. Celecoxib, Zafirlukast).
As such, it will be irrelevent to compare this data with the blood
levels after topical administration except that u can get some good
estimate of the flux rate through mass balance( estimated AUC). As u
said u are in preclinical phase of investigations so its advisable to
study the flux rate by making use of any suitable model.
I hope this makes sense.
Kind regards,
Pradeep S. Bhadauria
Research Scientist,
Ranbaxy Research Laboatories,
INDIA.
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