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The following message was posted to: PharmPK
Hi,
I am modeling some intravenous data from cats given a lidocaine bolus.
We
have both lidocaine and the active metabolite, MEGX, concentrations at
the
same time points. In terms of modeling the active metabolite, is it more
appropriate to use a compartmental or noncompartmental model? If
compartmental, how do I choose which one? Thank you very much!
Sincerely,
Sara Thomasy
Graduate Student
Equine Analytical Chemistry Laboratory
California Animal Health and Food Safety Lab
(530) 754-5339
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The following message was posted to: PharmPK
Dear Sara
I would recommend you use the method exemplified in our study
L. Dedík, M. Durisová, System approach to modeling metabolite
formation from parent drug: A working example with methotrexate.
Meth. Find. Exp. Clin. Pharmacol. 24, 481-486 (2002).
Regards,
Maria
Maria Durisova, PhD, DSc (Math/Phys),
Head of Department of Pharmacokinetics
and Scientific Secretary
Institute of Experimental Pharmacology
Slovak Academy of Sciences
841 04 Bratislava 4
Slovak Republic
Phone/Fax: +421 2 54775928
http://www.uef.sav.sk/durisova.htm
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