PharmPK Discussion - Anesthetised Rodent model of Asthma

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On 1 May 2003 at 20:32:53, b pradeep (pradeepbhadauria.-a-.sify.com) sent the message


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Dear All,

Does anybody have any reference for the Anesthetised Rodent model of
Asthma by whole body plethysmography and measurement of dynamic
compliance and lung resistance.

Any help in this regard is appreciated in advance.

Kind regards,
Pradeep S. Bhadauria
RANBAXY RESEARCH LABORATORIES,
INDIA.

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On 2 May 2003 at 11:32:54, "Zutshi, Anup [R&D/0216]" (anup.zutshi.aaa.pharmacia.com) sent the message


The following message was posted to: PharmPK

Pradeep

Call Battelle Memorial Institute, Columbus, OH for answers. They
routinely
use anesthetized rodents to establish compliance and resistance in lungs
through whole body pleythsmography. Although they do not specifically
have
an asthma model, (I don't know of one that exists except in guinea pigs
---
but that is only as an early stage of asthma model and is difficult to
set
up)they can accomplish methacholine (or any other chemically
induced)induced
broncho-constrictions and study the effectiveness of your drug to
reverse
the effect.

Contact persons:

Mr. Paul Grothaus, Marketing, (614)424-7828
Dr. Craig Hassler, Cardiovascular Pharmacology, (614) 424-7623
Dr. Ron Moutvic, Pulmonologist, (614) 424-4217

Good Luck

Anup Zutshi Ph.D.
PDM; Pfizer
(269)833-8347
Anup.Zutshi.aaa.Pfizer.com

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