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The following message was posted to: PharmPK
Dear all
I am working on ascending multiple dose parallel study, which consists
of 5 dose levels (doses were given b.i.d for 7 days), I want to
statistically analyze the dose proportionality and linear kinetics of
the compound at steady state (morning dose of day 7) using ANOVA or
ANCOVA module of WinNonLin Prof. (Version 4).
In one of the similar published paper, I have seen that this was done
by ANCOVA, the dose normalized pharmacokinetic parameters were assessed
separately for a linear trend with dose (as test statistic). But my
question is how to put this linear trend with dose as test statistic in
the WinNonLin. I appreciate a detailed step by step procedure.
Thanks in advance
JAYASAGAR GUNDU
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The following message was posted to: PharmPK
I have had very good luck getting help from the folks at Pharsight. They
will walk you right through it over the phone.
Shelly Dunnington R.Ph., Ph.D.
DunningtonShelly.-at-.praintl.com
913-577-2767
16400 College Blvd.
Lenexa, KS 66219
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