Back to the Top
The following message was posted to: PharmPK
In calculating AUC0-inf, WinNonlin use the formula: AUC0-inf=
AUC0-last+Clast/K, where Clast is the last measurable concentration and
K is the elimination rate constant. The question is does WinNonlin use
the same value of AUC0-last when calculating AUC0-inf. As an example if
AUC0-last = 100, dose this value is used to calculate AUC0-inf or a
different value?. Please let me know.
Regards,
Aqel Abu-Qare
Back to the Top
The following message was posted to: PharmPK
Dear Aqel - WinNonlin computes AUCinf in two ways. AUCinf(obs) uses the
last observed concentration for Clast while AUCinf(pred) used the
predicted concentration for Clast (based on the regression used to
estimate the terminal elimination rate, lambda z).
Dan Weiner
Back to the Top
The following message was posted to: PharmPK
Dear Dr. Abu-Qare,
The AUClast that is used to calculate AUC0-inf in WinNOnlin is in fact
the same value (100 in your example) reported as AUClast.
Ana Henry
PK Automation Specialist
Pharsight Corporation
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)