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The following message was posted to: PharmPK
Dear All,
Hello!
I have started working on pharmacokinetic modeling of drug metabolism
and disposition. I want to use the compartmental model and also want to
include the interstitial fluid flow too in my model. Can anyone suggest
me the some literature which is available free on-line in this field?
Please also suggest me some references for the basic principles of
compartmental modeling of drug metabolism and disposition.
With regards,
Jyoti
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Dear Jyoti:
You might go to our web site, www.lapk.org, and look under
teaching topics, for literature on population modeling and how to plan,
monitor, and adjust individualized drug dosage regimens. We also have
software for population modeling, especially nonparametric modeling.
Again, this is discussed in teaching topics.
Very best regards,
Roger Jelliffe
Roger W. Jelliffe, M.D. Professor of Medicine,
Division of Geriatric Medicine,
Laboratory of Applied Pharmacokinetics,
USC Keck School of Medicine
2250 Alcazar St, Los Angeles CA 90033, USA
Phone (323)442-1300, fax (323)442-1302, email= jelliffe.-a-.usc.edu
Our web site= http://www.lapk.org
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[Two replies - db]
From: "Dhanesh Gupta"
Date: Tue Jan 28, 2003 7:25:50 AM US/Central
To: david.at.boomer.org
Subject: Re: PharmPK Basic Principles
Reply-To: "Dhanesh Gupta"
The following message was posted to: PharmPK
Arthur Atkinson's group (when he was at Northwestern) had several papers
on interstitial drug disposition (Stec is the first author). Michael
Avram, Tom Henthorn, and Tom Krejcie (also at Northwestern) have models
that deal with the distribution of indocyanine green (intravascular
space marker), inulin (interstitial space marker), and antipyrine (total
body fluid space marker) administered concomitantly with drugs such as
lidocaine, ketamine, and thiopental. Many of these papers are not
available on-line, but easily available in JPET or CPT.
Dhanesh
---
From: "Prof. Walter Wolf"
Date: Tue Jan 28, 2003 8:09:38 AM US/Central
To: david.aaa.boomer.org
Subject: Re: PharmPK Basic Principles
Reply-To: "Prof. Walter Wolf"
The following message was posted to: PharmPK
Jyoti:
One of the key premises is that our ability to develop a good
understanding of drug biodistribution and metabolism is determined by
what we can measure. As long at such measurements were confined (in
humans) to blood and other accessible body fluids, it was practically
impossible to generate a meaningful understanding of the events that
occurr at a given target site. That is why we developed an approach we
have called Pharmacokinetic Imaging, that uses noninvasive methods
(MRI, MRS and Nuclear Imaging) to measure DIRECTLY and nonincvasively
drugs and their metabolites at the target sites. We have now expanded
this approach by measuring simultaneously selected pharmacodynamic
effects at such target sites, allowing a direct PK/PD analysis of a
drug in a specific patient.
The following are some of the key publications where this approach is
discussed in more detail, and I will be glad to e-mail you (and anyone
else interested) copies of these papers.
Imaging Can be Much More Than Pretty Pictures. Walter Wolf.
Pharmaceutical Research, 12, 1821-1822, 1995
Noninvasive 19F-NMRS of 5-Fluorouracil in Pharmacokinetics and
Pharmacodynamic Studies. Walter Wolf, Victor Waluch and Cary A.
Presant. NMR in Biomedicine. 11: 380-387,1998.
19F-MRS Studies of Fluorinated Drugs in Humans. Walter Wolf, Cary A.
Presant and Victor Waluch. Advanced Drug Delivery Reviews, 41, 55-74,
2000
Professor Walter Wolf, Ph.D. Distinguished Professor of Pharmaceutical
Sciences
Director, Pharmacokinetic Imaging Program
Department of Pharmaceutical Sciences, School of Pharmacy
University of Southern California 1985 Zonal Ave., Los Angeles, CA
90089-9121
E-Mail: wwolfw.aaa.usc.edu
Telephone: 323-442-1405
Fax: 323-442-9804
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)