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The following message was posted to: PharmPK
Hello
I am interested to characterize drug induced nephrotoxicity by means of
measuring biomarker concentration and/or GFR. The drugs of interest
(cyclosporine and tacrolimus) are known to be toxic to the proximal
part of
the nephrons.
Many thanks in advance.
Fatemeh Akhlaghi, PharmD, PhD
Assistant Professor
Applied Pharmaceutical Sciences
University of Rhode Island
125 Fogarty Hall, 41 Lower College Road
Kingston, RI 02881
Phone: (401) 874 9205
Fax: (401) 874 2181
email: fatemeh.at.uri.edu
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The following message was posted to: PharmPK
Dear Fatemeh
Animal model or Human study?
Dr.Prashant
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Dear Fatemeh,
For proximal tubular damage there are a number of good markers that can
be used both in animals and in humans. The classical blood urea and
creatinin concentrations are quite sentitive markers for tubular damage
as is the creatinine clearance. In urine the amount of total protein
can be used, but more sensitive is a quantitative measurement of
glucise in urine (very simple). There are also a number of soecific
markers for tubular function like NAG, but in our hands, the classical
ones tend to be the most predictive and reliable.
Hope this helps,
Anja Slikkerveer,
Senior toxicologist
Leiderdorp, the Netherlands
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