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Hello Sir/Madam,
We aregenerating PK parmeters of a poorly water soluble drug
developed by our own organization. Since the drug falls in poorly
soluble category, which islimitingits dose givenorally, even with
formulation excipients. Should we continue the insitu studies at
sub-saturation solubility level, wemightloose important information
of the drugs absorption pattern while above thislevelformulation
ingredients mightinterfere considerably. We would like to know about
criteria for selection of dose level in such situations.
Regards
Nitin
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