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The following message was posted to: PharmPK
Dear Dr.Srikanth,
Nice to see your comments on my points. Actually, the dilution
principle what ever you applied for the DMSO solution of the
oxazolidinone you are having will not work as it may precipitate your
compound(As seen by you).On the contrary, as far as cyclodextrin is
concerned, the phenomenon is complexation. The complex that is formed
is soluble in water. So you can dilute the cyclodextrin solution of the
oxazolidinoneto the strength you require using water, as the complex
of your oxazolidinone or to that matter any compound formed with
cyclodextrin is soluble in water.The only problem you may face at
higher strenghts of cyclodextrin is the viscosity.
Regards
Ravi Kanth Bhamidipati
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The following message was posted to: PharmPK
Dear all,
A problem with the use of cyclodextrins is that you first have to ensure
that the complexation will not interfere with the active
bioavailability. I
did not follow this discussion from start so I don't know if you intend
to
use this formulation per iv or by another route of administration. But
you
certainly have to consider the complexation between the cyclodextrin
and the
active using some complexation constant calculation described in the
literature.
I hope this helps,
Frederic
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Dear Frederic
Thanks for your comments. Actually, i posted that question and there
was a lot of advices to formulate our oxazolidinone based compound.
There are couple of Pfizer's drugs that FDA approved recently with HPCD
and SBECD based cyclodextrins through I.V. and Oral routes. I hope the
complexation will not interfere with the Bioavailability of the drug.
Dr. Sreekanth Gutala
Sreekanth Gutala
sgutala.-at-.hotmail.com
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