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The following message was posted to: PharmPK
Dear All,
I am working on formulation development of Glimepiride Tablets. In few
days we are going to start the Bio-equivalence study on the same,
against the innovator product. With reference to the same, I am in need
of the following information:
1. Does any one have some data / references on In vitro - In vivo
correlation for the said molecule.
2. Does any one ever had an experience with such study? If yes, could
you please share with us your experiences.
Request you to please help.
Thanking you all, in advance.
Warm regards,
Hitesh Maheshwari
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dear maheshwari,
i thank that molecule is comming under class poory soluble and highly
permeable.do in vitro dissln in water or 0.1N HCL with surfactant like
sls or tween 80,match innovator and do F1 &F2.i womt think u will get
problem.
revert to what u feel.
jagadeesh T
Research Associate.
NDDS
079 31098990
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