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The following message was posted to: PharmPK
Does anyone have any figures for the average total human and rat gut
volume?
Any information would be greatly appreciated!
Many Thanks,
Constance
Dr Constance Hoefer
Department of Clinical Candidate Selection
Solvay Pharmaceuticals GmbH
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The following message was posted to: PharmPK
Try:
http://www.icrp.org/pdf/c_REM_Chapter_2_Reference_Values.pdf
for reference values on the content weight of the GI tract organs.
Assuming
a density of 1-1.2 should get you the volumes.
Also see this publication and other work by the same group
Chowdhury, B., L. Sjostrom, et al. (1994). "A multicompartment body
composition technique based on computerized tomography." Int J Obes
Relat
Metab Disord 18(4): 219-34.
For direct measurements of GI volumes.
Paul S. Price, Director
Linea Inc.
129 Oakhurst Rd.
Cape Elizabeth, ME 04107
Phone 1 207 799 3406
Fax 1 207 799 2529
psprice.aaa.thelifelinegroup.org
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The following message was posted to: PharmPK
Constance
with regard to RAT volume we use the following volumes
in our in situ persfusion experiments without any
problem:
Stomach 3 mL
Small intestine: 10 mL, average lenght 100 cm
Colon: 5ml average lenght 10 cm
hope this helps
Marival
MariVal BERMEJO
Associate Professor of Pharmaceutics
Departamento Farmacia y Tecnologia Farmaceutica
Facultad de Farmacia. Universidad de Valencia
Av. Vicente A. Estelles sn Burjassot 46100
Valencia
Espaņa
mailto:mbermejo.-a-.uv.es
http://www.uv.es/~mbermejo/absorption.htm
Tel. +34.963544916 (direct)
Fax. +34.963544911
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Constance,
For humans, you will find several pages of tabulated data in ICRP
publication 23 "Report of the Task Group on Reference Man", published
by Pergamon Press
Also, the following paper:
B. Davies, T. Morris, Physiological parameters in laboratory animals
and humans, Pharm Res 10(7)1093-1095, 1993
gut volume human (70kg) = 1650 mL
gut volume rat (0.25 kg) = 11.3 mL
rgds
Armel Stockis
UCB Pharma
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The following message was posted to: PharmPK
Constance,
as I see there are some interesting answers to your question.
To add on this topic I would ensure that you also consider the
differences between rat and human gut physiology. Rats have a
"constant" delivery of enzymes as their GI tract is never empty. This
can be of major impact as compared to humans where the enzyme secretion
is led by the fed and the fasted states.
I hope this is useful to you.
Regards,
Frederic
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The following message was posted to: PharmPK
you may find some relevant data in our report on interspecies
differences.
The pdf of this report is to be found on our website:
http://www.rivm.nl/bibliotheek/rapporten/623860010.html
Kind regards,
Adrienne Sips, PhD
National Institute of Public Health & the Environment
Center for Substances and Integrated Risk Assessment, U339
P.O. Box 1
3720 Bilthoven
The Netherlands
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Dear Dr. Constane
During my graduation days i used to refer a encyclopedia called
Handbook of Biochemistry. unfortunately i do not rememder the
publishers, and other details. This handbook had a huge compilation of
anatomical, physiological and biochemical data (and data tables) for
various animals used in research (including Human).
Check if any library has that handbook.
with regards
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