Back to the Top
Hi,
can anyone tell me if and to what extent after intra peritoneal
administration, substance pass through the liver before reaching the
systemic circulation. In other words is there any chance for the first
pass effect.
Thanks
Sinisa Stipanicic
Back to the Top
The following message was posted to: PharmPK
No hepatic extraction (first pass metabolism) possible via IP route.
Regards
Pradeep Bhadauria
Back to the Top
The following message was posted to: PharmPK
Pradeep:
Correct me if I am wrong. But my understanding of anatomy is that the
mesenteric vein system is collected into the portal vein and hence that
ALL products drained from the mesenterium are cleared through the liver.
Professor Walter Wolf, Ph.D. President, Correlative Imaging Council,
Society of Nuclear Medicine
Distinguished Professor of Pharmaceutical Sciences
Director, Pharmacokinetic Imaging Program
Department of Pharmaceutical Sciences, School of Pharmacy
University of Southern California 1985 Zonal Ave., Los Angeles, CA
90089-9121
E-Mail: wwolfw.-at-.usc.edu
Telephone: 323-442-1405
Fax: 323-442-9804
Back to the Top
The following message was posted to: PharmPK
Dear Pradeep,
The statement "no hepatic extraction possible via IP route" is at odds
with previous conclusions reached by this forum. See 'Intraperitoneal
absorption of drugs' posted on PharmPK on April 17 and 18, 2000.
Best regards,
Jackie
Back to the Top
The following message was posted to: PharmPK
Hello Sinisa,
anatomically the veins of the peritoneum viscerale lead to the portal
vein,
i.e., liver must be passed.
Experimentally it was demonstrated by LUCAS et al., J Pharmacol anf Exp
Therap, 178 (8), 1971, in dog and rat: "The results demonstrate, that
compounds administered i.p. are absorbed primarily through the portal
circulation and, therefore must pass through the liver before reaching
the
other organs."
best regards
Hans Markus
Dr. Hans Markus Bender
Merck KGaA
Institute of Drug Metabolism and Pharmacokinetics
Am Feld 32
D-85567 Grafing
[Germany]
Tel: 08092 / 7008-14
Fax: 08092 / 7008-99
e-mail: hansmarkus.bender.-a-.merck.de
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)