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I appreciate if someone can guide me towards good publications on how
you arrive at the dose calculations of a potential trandermal product
based on the available oral or IV dosing. In addition what are the
pysico-chemical and pharmacokinetic factors that one need to consider
on doing the guess workon the dose of patch product.
Thanks in advance.
Prasad
Prasad NV Tata, M.Pharm., Ph.D.
Dept. of Clinical and Regulatory Affairs
Mallinckrodt, Inc.
675 McDonnell Blvd.
Saint Louis, MO 63134-5840
Tel: (314) 654-5325
Fax: (314) 654-9325
e-mail: prasad.tata.-a-.tycohealthcare.com
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The following message was posted to: PharmPK
Dear Prasad,
Please see below one publication where you can find the in vitro based
estimation of the concentration at steady state that would provide seven
NSAIDs administered to humans by transdermal route. Calculations are
based
on the in vitro permeation data across human skin, the pharmacokinetic
parameters and the patch surface. Additionally, you can find a multiple
linear correlation where the permeability rate constants of the series
can
be in part explained by physicochemical parameters such as lipophilia
(logP) and MW.
I hope this helps.
José-Antonio Cordero, Ph.D.
Pharmacokinetics Dept.
Ipsen Pharma
Barcelona
Spain
J Pharm Sci. 1997 Apr;86(4):503-8
"A comparative study of the transdermal penetration of a series of
nonsteroidal antiinflammatory drugs"
J. A. Cordero, L. Alarcon, E. Escribano, R. Obach, J. Domenech *
http://www.ncbi.nlm.nih.gov/entrez/
query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9109056&dopt=Abstract
PharmPK Discussion List Archive Index page
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