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Yes, an infection can definitely affect the pharmacokinetics of drugs.
If you do a search on inflammation and pharmacokinetics, or look for
the following researchers who have publications in this area: Dr.
Piquette-Miller, Dr. Renton, Dr. Jamali.
Julie Kalitsky-Szirtes
Associate Pharmacokineticist
Apotex Research Inc.
Biometrics Unit, Biomedical Division
Phone: (416) 749-9300 (EXT 8698)
jszirtes.-a-.apotex.com
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The following message was posted to: PharmPK
As cited below, inflammation can affect the PK of drugs. One additional
consideration is noted in
Antimicrob Agents Chemother 2001 Mar;45(3):852-6
In vivo effect of alpha(1)-acid glycoprotein on pharmacokinetics of
amprenavir, a human immunodeficiency virus protease inhibitor.
Sadler BM, Gillotin C, Lou Y, Stein DS.
AAG increases in response to infection, trauma, and other stimuli. Drugs
that are primarily bound to AAG can demonstrate apparent changes in PK
when
based upon total drug concentrations. The underlying PK of free drug
may be
unaltered if there is no accompanying change in intrinsic clearance.
Best regards...
Brian Sadler
Strategic PK Consulting, LLC
bsadler1.at.nc.rr.com
919-523-5485 (mobile)
919-845-0670 (facsimile)
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